feasibility of cell therapy in multiple sclerosis: a systematic review of 83 studies.

Authors

abdolreza ardeshiry lajimi stem cell biology department, stem cell technology research center, tehran, iran.

majid farshdousti hagh division of laboratory hematology and blood banking, faculty of medicine, tabriz university of medical sciences, tabriz, iran.

najmaldin saki research center of thalassemia & hemoglobinopathy, ahvaz jundishapur university of medical sciences, ahvaz, iran.

esmaeil mortaz division of pharmacology and pathophysiology, utrecht institute for pharmaceutical sciences, faculty of sciences, utrecht university, utrecht, the netherlands.

abstract

multiple sclerosis is an inflammatory disease of the central nervous system in which t cells experience a second phase of activation, which ultimately leads to axonal demyelination and neurological disability. the recent advances in stem cell therapies may serve as potential treatments for neurological disorders. there are broad types of stem cells such as neural, embryonic, mesenchymal and hematopoietic stem cells with unprecedented hope in treating many debilitating diseases. in this paper we will review the substantial literature regarding experimental and clinical use of these stem cells and possible mechanisms in the treatment of ms. these results may pave the road for the utilization of stem cells for the treatment of ms.

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Journal title:
international journal of hematology-oncology and stem cell research

جلد ۷، شماره ۱، صفحات ۱۳-۳۰

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